A parallel fully-coupled fluid-structure interaction simulation of a cerebral aneurysm

A parallel fully-coupled approach has been developed for the fluid-structure interaction problem in a cerebral artery with aneurysm. An Arbitrary Lagrangian-Eulerian formulation based on the side-centered unstructured finite volume method [2] is employed for the governing incompressible Navier-Stokes equations and the classical Galerkin finite element formulation is used to discretize the constitutive law for the Saint VenantKirchhoff material in a Lagrangian frame for the solid domain. A special attention is given to construct an algorithm with exact fluid mass/volume conservation while obeying the global discrete geometric conservation law (DGCL). The resulting large-scale algebraic linear equations are solved using a one-level restricted additive Schwarz preconditioner with a block-incomplete factorization within each partitioned sub-domains. The parallel implementation of the present fully coupled unstructured fluid-structure solver is based on the PETSc library for improving the efficiency of the parallel algorithm. The proposed numerical algorithm is applied to a complicated problem involving unsteady pulsatile blood flow in a cerebral artery with aneurysm as a realistic fluid-structure interaction problem encountered in biomechanics

Crypto Currencies and their Destinies in the Future

In this article the features of Crypto Currencies, which are not backed by governments, are investigated with regards to their specialties, usage areas and current structures. In this context the newly invented crypto currencies are compared with currency types that were in use in different periods of history. A similarity between Crypto Currencies and Free Banking Era Banknotes is noticed and thus investigated in details. The possible risks and outcomes with regards to the future usage of crypto currencies are analyzed and elaborated

The role of oxidative stress and effect of alpha-lipoic acid in reexpansion pulmonary edema – an experimental study

Introduction: We investigated the role of oxidative stress in the pathogenesis of reexpansion pulmonary edema (RPE) and effect of alpha-lipoic acid (ALA) in the prevention of RPE

Utilization of Water Hyacinth and Banana Wastes Compost in Reclamation of Sandy Soils for Increasing Growth, Yield of Cowpea

Pot experiments were carried out in the greenhouse of the Faculty of Agriculture, Fayoum University, to study the effect of water hyacinth and banana wastes compost (0, 10, 15 and 20 ton/fed) combined with inorganic nitrogenous fertilizers namely ammonium sulphate, ammonium nitrate and urea (in the rate of 60 kg N/Fed and this rate was 50% of the recommended dose), on the growth, yield and nutrient content of cowpea plants. All pots received P and K as recommended. The addition of various rates of water hyacinth and banana wastes composts (H.B.C.) under study significantly increased all plant growth parameters under the study, i.e., plant height, plant fresh weight and dry weight of both shoots and roots, the number of root nodules as well as the nutrient content of the different plant organs compared with the control and the chemical fertilizer application of the recommended dose (100%). There was a marked increase in pod characters, yield and its components, i.e., number of pods per plant, length, diameter and weight of pods per plant. The highest values of growth characters of yield and its components and the contents of nutrient elements were noticed when applying compost at the higher rates (20 ton/fed.) followed by 15 and 10 ton/fed., in a descending order as compared with the control. The best combination of nitrogen forms and the compost is considered to be one of the primary factors for high yield production and quality as well as yield components of cowpea. The highest significant increase in growth characters, yield and yield components, as well as the total carbohydrates and crude protein content of the seeds, were obtained via the application of compost in combination with ammonium sulphate at the rate of 20 ton/fed

Fingolimod Alters Tissue Distribution and Cytokine Production of Human and Murine Innate Lymphoid Cells

Sphingosine-1 phosphate receptor 1 (S1PR1) is expressed by lymphocytes and regulates their egress from secondary lymphoid organs. Innate lymphoid cell (ILC) family has been expanded with the discovery of group 1, 2 and 3 ILCs, namely ILC1, ILC2 and ILC3. ILC3 and ILC1 have remarkable similarity to CD4+ helper T cell lineage members Th17 and Th1, respectively, which are important in the pathology of multiple sclerosis (MS). Whether human ILC subsets express S1PR1 or respond to its ligands have not been studied. In this study, we used peripheral blood/cord blood and tonsil lymphocytes as a source of human ILCs. We show that human ILCs express S1PR1 mRNA and protein and migrate toward S1P receptor ligands. Comparison of peripheral blood ILC numbers between fingolimod-receiving and treatment-free MS patients revealed that, in vivo, ILCs respond to fingolimod, an S1PR1 agonist, resulting in ILC-penia in circulation. Similarly, murine ILCs responded to fingolimod by exiting blood and accumulating in the secondary lymph nodes. Importantly, ex vivo exposure of ILC3 and ILC1 to fingolimod or SEW2871, another S1PR1 antagonist, reduced production of ILC3- and ILC1- associated cytokines GM-CSF, IL-22, IL-17, and IFN-γ, respectively. Surprisingly, despite reduced number of lamina propria-resident ILC3s in the long-term fingolimod-treated mice, ILC3-associated IL-22, IL-17A, GM-CSF and antimicrobial peptides were high in the gut compared to controls, suggesting that its long term use may not compromise mucosal barrier function. To our knowledge, this is the first study to investigate the impact of fingolimod on human ILC subsets in vivo and ex vivo, and provides insight into the impact of long term fingolimod use on ILC populations

Athletic performance, sports experience, and exercise addiction: an association study on ANKK1 gene polymorphism rs1800497

IntroductionExercise addiction is a phenomenon being able to affecting the athletic performance. The gene, ANKK1 and the polymorphism NM_178510.2:c.2137G > A (rs1800497) has been linked to the exercise addiction. However, further studies on diverse populations and sport branches are needed to totally explore the possible association of this polymorphism with the athletic performance. Thus, the present study aims to decipher any possible relations of the rs1800497 polymorphism with the athletic performance/personal best (PB) and sport experience of elite athletes.MethodsSixty volunteer elite athletes (31 sprint/power and 29 endurance) and 20 control/sedentary participated in the study. The polymorphism was genotyped using whole exome sequencing approach and PB were determined according to the International Association of Athletics Federations (IAAF) score.ResultsOur results underlined that there were not any significance differences for both allele and genotype frequencies between the groups in terms of athletic performance, although the frequency of allele G was higher (p > 0.05). Nevertheless, sport experience significantly associated with the rs1800496 polymorphism (p < 0.05).DiscussionIn conclusion, genotype G/G could be inferred to be linked to the higher sport experience and athletic performance. Still, further studies with higher number of participants are needed to conclude the association of this polymorphism with athletic parameters

ARGO DI DEVOKA AMEDÊ DE

Her çandek û deverek xwediyê argoyên xwe yên taybet in. Ev argo li gor şert û mercên dîrokî, erdnîgarî, civakî, folklorî û aborî, di nav salan de rengê xwe girtine û heya îro hatine. Ev argoyên ku tên bikaranîn bi giştî bo deverên kurd lê dijîn, taybet ji bo devera Amed jî derbas dibe. Ev çanda argoyên ku bi guherîneke berdewam digihîje roja me, ji ber pêşketina televizyon, radyo û jiyana modern hêdî hêdî winda dibe. Divê ev argoyên ku li ber mirinê ne, bêne tespîtkirin, danasîn û ji bo dahatûyê bêne neqilkirin. Ji bo vê jî em ê di vê xebata xwe de li bajara Amedê argoyên ku tên bikaranîn bi alikariya pirtûk, stran, helbest û kesayetan kom bikin. Piştê komkirina argoyan em ê wateya wan li hemberê wan binivîsînin. Beriya wan jî em ê li ser erdnigarî û dîrokî ya Amedê agahiyan bidin paşê wateya ziman, zimanê dayîkê, zarava, devok werin dayîn û bi mînakan xebat were xurt kirin.Her kültür ve bölge kendine has argolara sahiptir. Bu argolar tarihi, çoğrafi, sosyal, folklorik ve ekonomik şartlardan dolayı yıllar içinde rengini almış ve günümüze ulaşmışlardır. Bu kullanılan argolar Kürt bölgelerinde var olmakla birlikte özelllikle Diyarbakır şehrinde kullanılmaktadır. Bu argo kültürü ki sürekli değişim ile günümüze gelirken televizyon, radyo ve modern yaşamın gelişmesinden dolayı yavaş yavaş kaybolmaktadır. Bu ölüm döşeğinde olan argo kelimelerin tespit edilip açıklandıktan sonra gelecek kuşaklara nakil edilmelidir. Bu yüzden de bu çalışmamızda Diyarbakır’da kullanılan argoları kitap, müzik, şiir ve şahıslar aracılığıyla toplayacağız. Bu argoları topladıktan sonra anlamlarını karşılarına yazacağız. Bunlardan önce ise Diyarbakır’ın çoğrafyası ve tarihi hakkında bilgi verip ardından dil, anadil, lehçe, ağız gibi kavramların anlamları verilecek ve örnekler ile bu çalışma kuvvetlendirilecektir